The Mouse monoclonal antibody Anti-Human FBXO18 from MyBioSource.com is a Mouse Monoclonal antibody to F-Box Protein 18, Fbh1, Fbx18, and FBXO18. This antibody recognizes Human antigen. The Mouse monoclonal antibody Anti-Human FBXO18 has been validated for the following applications: Dot Blot, and Immunocytochemistry.
Description
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [NCBI Entrez Gene Summary]